How does avacopan reduce inflammation?

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Avacopan selectively blocks the C5a receptor C5aR1, preventing C5a interaction and reducing its pro-inflammatory effects, including neutrophil activation, migration and adherence at inflamed small blood vessels, and vascular endothelial cell retraction and permeability.

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Avacopan Vifor 10 mg hard capsulesVifor Fresenius Medical Care Renal Pharma UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 7Document updated 12 May 2025

Sources checked 8 November 2026

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