Answer
In a clinical study, avacopan increased simvastatin total systemic exposure (AUC) 3.5-fold and peak plasma concentration (Cmax) 3.2-fold; the simvastatin Summary of Product Characteristics should be consulted for appropriate dose adjustments.
Sources for this answer
- Avacopan Vifor 10 mg hard capsulesVifor Fresenius Medical Care Renal Pharma UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 7Document updated
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