Answer
Grapefruit juice should be avoided during pirfenidone treatment because it inhibits CYP1A2, the enzyme responsible for metabolising approximately 70–80% of pirfenidone.
Sources for this answer
- Esbriet 267 mg, 801 mg Film-coated TabletsRoche Products Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 14Document updated
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