Answer
Fluvoxamine is contraindicated with pirfenidone because it inhibits CYP1A2 and other enzymes involved in pirfenidone metabolism, reducing clearance and causing a fourfold increase in pirfenidone exposure in a study of non-smokers.
Sources for this answer
- Esbriet 267 mg, 801 mg Film-coated TabletsRoche Products Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 14Document updated
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