Answer
Voxelotor may increase exposure to tacrolimus, a sensitive CYP3A4 substrate with a narrow therapeutic index, so concomitant use should be avoided; if unavoidable, consider reducing the tacrolimus dose.
Sources for this answer
- Oxbryta 500 mg film-coated tabletsPfizer Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 5Document updated
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