Safinamide · Medicine question

Why must safinamide not be taken with moclobemide?

iatroX medicinesPublished 8 November 2026

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Safinamide must not be taken with moclobemide because combining these MAO inhibitors risks non-selective MAO inhibition, which may lead to a hypertensive crisis.

Sources for this answer

Safinamide 50 mg film-coated tabletsMSN Laboratories Europe Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated 24 November 2025

Sources checked 8 November 2026

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