Safinamide · Medicine question

Is safinamide contraindicated with pethidine?

iatroX medicinesPublished 8 November 2026

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Safinamide is contraindicated with pethidine because serious adverse reactions reported with pethidine and MAO inhibitors may represent a class effect.

Sources for this answer

Safinamide 50 mg film-coated tabletsMSN Laboratories Europe Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated 24 November 2025

Sources checked 8 November 2026

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