Answer
St John's wort is a strong CYP3A4 inducer that reduced eplerenone exposure (AUC) by 30%, so taking them together is not recommended because eplerenone may become less effective.
Sources for this answer
- Inspra 25 mg Film-coated TabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §4.5 Interaction with other medicinal products · Version 17Document updated
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