sotorasib · Medicine question

Why is taking sotorasib with rifampicin not recommended?

iatroX medicinesPublished 8 November 2026

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Taking sotorasib with rifampicin is not recommended because this strong CYP3A4 inducer decreases sotorasib exposure (Cmax by 35% and AUC by 51% with multiple inducer doses), and the impact on sotorasib efficacy is unknown.

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LUMYKRAS 240 mg film-coated tabletsAmgen Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 3Document updated 15 July 2026

Sources checked 8 November 2026

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