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Medicines sotorasibQuestion & answer

sotorasib · Medicine question

How does sotorasib affect digoxin concentrations?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Co-administration of sotorasib with digoxin increased digoxin peak concentration (Cmax) by 91% and overall exposure (AUC) by 21%.

Sources for this answer

LUMYKRAS 240 mg film-coated tabletsAmgen Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 3Document updated 15 July 2026

Sources checked 8 November 2026

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sotorasib

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