Answer
Taking rifampicin with Kaftrio is not recommended because rifampicin strongly induces CYP3A, reducing ivacaftor exposure by 89% and potentially reducing efficacy, while elexacaftor and tezacaftor exposures are also expected to decrease.
Sources for this answer
- Kaftrio 75 mg/50 mg/100 mg film-coated tabletsVertex Pharmaceuticals (Europe) Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 16Document updated
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