How does itraconazole affect exposure to the active ingredients in Kaftrio?

Itraconazole, a strong CYP3A inhibitor, increases exposure (AUC) to Kaftrio's elexacaftor by 2.8-fold, tezacaftor by 4.0–4.5-fold and ivacaftor by 15.6-fold; doses of Kaftrio and accompanying ivacaftor should therefore be reduced.