Answer
Emtricitabine/tenofovir disoproxil with didanosine is not recommended because didanosine exposure rises 40–60%, increasing toxicity risk, including rare, sometimes fatal pancreatitis and lactic acidosis; didanosine 400 mg daily has been linked to CD4 decreases, and 250 mg to high virological failure rates in several HIV-1 combinations.
Sources for this answer
- Emtricitabine/Tenofovir Disoproxil Mylan 200 mg/245 mg Film-coated TabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §4.5 Interaction with other medicinal products · Version 9Document updated
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