Answer
Emtricitabine/tenofovir disoproxil inhibits HIV-1 replication through emtricitabine triphosphate and tenofovir diphosphate, formed by cellular phosphorylation after tenofovir disoproxil converts to tenofovir, which competitively inhibit HIV-1 reverse transcriptase and terminate DNA chains.
Sources for this answer
- Emtricitabine/Tenofovir Disoproxil Mylan 200 mg/245 mg Film-coated TabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §5.1 Pharmacodynamic properties · Version 9Document updated
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