Answer
With emtricitabine/tenofovir disoproxil, ledipasvir/sofosbuvir increases plasma tenofovir concentrations, especially when the HIV regimen also contains ritonavir or cobicistat; the safety of this enhanced combination has not been established.
Sources for this answer
- Emtricitabine/Tenofovir Disoproxil Mylan 200 mg/245 mg Film-coated TabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §4.4 Special warnings and precautions for use · Version 9Document updated
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