ibrutinib · Medicine question

Why is St John's wort contraindicated during ibrutinib treatment?

iatroX medicinesPublished 8 November 2026

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St John's wort is contraindicated during Imbruvica (ibrutinib) treatment because CYP3A4 induction can decrease ibrutinib plasma concentrations and reduce efficacy.

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IMBRUVICA 140 mg film-coated tablets (Great Britain)Janssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §4.5 Interaction with other medicinal products · Version 25Document updated 26 May 2026

Sources checked 8 November 2026

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