skip to main content

brainstorm askiatroX medicines

simulations beta

loading page…

learn & practise

exams international doctors free questions Socratic Tutor rounds stat clinical connections academy journal tool guides

clinical reference

askiatroX knowledge centre medicines UK / NICE guidance international guidance calculators q&a library

trust & support

how it works methodology account & support frequently asked questions about us clinical safety consultancy

legal

mobile app · scan to download

Medicines ibrutinibQuestion & answer

ibrutinib · Medicine question

Which enzyme primarily metabolises ibrutinib?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Ibrutinib is primarily metabolised by cytochrome P450 enzyme 3A4 (CYP3A4).

Sources for this answer

IMBRUVICA 140 mg film-coated tablets (Great Britain)Janssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §4.5 Interaction with other medicinal products · Version 25Document updated 26 May 2026

Sources checked 8 November 2026

Explore this learning need in CPDTake this topic to CPD, then choose your learning context and available question library.

The full medicine guide

ibrutinib

Read the wider context, including uses, precautions and the sources behind this medicine guide.

More questions about ibrutinib

How can clarithromycin affect ibrutinib exposure?Why is St John's wort contraindicated during ibrutinib treatment?Has interstitial lung disease been reported with ibrutinib?How much lactose monohydrate does each Imbruvica (ibrutinib) 140 mg film-coated tablet contain?What liver problems have been reported with ibrutinib?What types of bleeding have been reported with ibrutinib?

Read the ibrutinib guide

More clinical questions?

Explore the tools and reference material available on iatroX.

Explore askiatroX