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Medicines ibrutinibQuestion & answer

ibrutinib · Medicine question

How can clarithromycin affect ibrutinib exposure?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Clarithromycin, a strong CYP3A4 inhibitor, may increase ibrutinib exposure (AUC) 14-fold, according to simulations under fasted conditions.

Sources for this answer

IMBRUVICA 140 mg film-coated tablets (Great Britain)Janssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §4.5 Interaction with other medicinal products · Version 25Document updated 26 May 2026

Sources checked 8 November 2026

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