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Medicines calcium folinate hydrateQuestion & answer

calcium folinate hydrate · Medicine question

Why is it given after methotrexate?

iatroX medicinesPublished 19 August 2026Reviewed 19 August 2026

The answer

Answer

It replenishes reduced folate in healthy cells and limits methotrexate toxicity while specialist monitoring guides rescue.

Sources for this answer

Calcium Folinate 10 mg/ml Injectionemc · SmPC Current selected SmPC · Version 18
Calcium Folinate 15mg Tabletsemc · SmPC Current selected SmPC · Version 14
Calcium folinate 10 mg/ml solution for injection/infusion

emc · SmPC Current selected SmPC · Version 1

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The full medicine guide

calcium folinate hydrate

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More questions about calcium folinate hydrate

Is calcium folinate hydrate the same as folic acid?Why is it given with fluorouracil?Can it treat methotrexate-related kidney damage?Can the tablets be split?Can it increase seizures?Can it be used for vitamin B12 deficiency anaemia?