Answer
Yes. It may reduce the effects of phenytoin, phenobarbital, primidone or succinimides and increase seizure frequency in susceptible people.
Sources for this answer
- Calcium Folinate 10 mg/ml Injection — Current selected SmPCemc · Summary of Product Characteristics
- Calcium Folinate 15mg Tablets — Current selected SmPCemc · Summary of Product Characteristics
- Calcium folinate 10 mg/ml solution for injection/infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.