Answer
Caution is advised when Mekinist (trametinib dimethyl sulfoxide) is taken with verapamil because verapamil strongly inhibits P-gp, and strong inhibition of hepatic P-gp may increase trametinib levels.
Sources for this answer
- Mekinist film-coated tabletsNovartis Pharmaceuticals UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 30Document updated
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