avapritinib · Medicine question

Why is avapritinib not recommended during pregnancy?

iatroX medicinesPublished 8 November 2026

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Avapritinib is not recommended during pregnancy because it may cause foetal harm, animal studies have shown reproductive toxicity, and there are no data on its use in pregnant women.

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AYVAKYT 300 mg film-coated tabletsBlueprint Medicines (Netherlands) B.V. · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 3Document updated 27 May 2026

Sources checked 8 November 2026

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