Answer
In healthy subjects, rifampicin 600 mg once daily for 18 days with a single 400 mg avapritinib dose on day 9 reduced avapritinib Cmax by 74% and AUC0-inf by 92% versus avapritinib alone; co-administration should be avoided.
Sources for this answer
- AYVAKYT 300 mg film-coated tabletsBlueprint Medicines (Netherlands) B.V. · emc · SmPC §4.5 Interaction with other medicinal products · Version 3Document updated
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