Why does avalglucosidase alfa (Nexviadyme) require caution in patients susceptible to fluid overload or with compromised heart or respiratory function?

Avalglucosidase alfa (Nexviadyme) requires caution because infusion may seriously worsen cardiac or respiratory status in patients susceptible to fluid overload or with compromised function requiring fluid restriction, so medical support and monitoring should be readily available and some patients may need prolonged observation.