Answer
Clarithromycin strongly inhibits CYP3A4, of which colchicine is a substrate, increasing blood colchicine concentrations and potentially causing toxicity, including fatal toxicity.
Sources for this answer
- Colchicine 500 micrograms TabletsWockhardt UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 9Document updated
Sources checked