Answer
Sodium benzoate in Orfadin (nitisinone) oral suspension can displace bilirubin from albumin, increasing bilirubin levels and worsening jaundice in preterm and full-term jaundiced newborns, potentially causing kernicterus, where unconjugated bilirubin deposits in brain tissue.
Sources for this answer
- Orfadin 4mg/ml Oral SuspensionSwedish Orphan Biovitrum Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 10Document updated
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