Answer
Nitisinone competitively inhibits 4-hydroxyphenylpyruvate dioxygenase in tyrosine metabolism, preventing accumulation of toxic maleylacetoacetate and fumarylacetoacetate in hereditary tyrosinaemia type 1 and harmful homogentisic acid in alkaptonuria.
Sources for this answer
- Orfadin 4mg/ml Oral SuspensionSwedish Orphan Biovitrum Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 10Document updated
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