tocilizumab · Medicine question

Which receptors does tocilizumab bind to and block signalling through?

Name: Which receptors does tocilizumab bind to and block signalling through?
Published: 2026-11-08T14:28:37.147Z

iatroX medicinesPublished 8 November 2026

The answer

Answer

Tocilizumab binds specifically to both soluble and membrane-bound interleukin-6 receptors (sIL‑6R and mIL‑6R) and inhibits signalling mediated by both receptors.

Sources for this answer

RoActemra 20mg/ml Concentrate for Solution for InfusionRoche Products Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 38Document updated 28 October 2026

Sources checked 8 November 2026

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