Answer
Yes, serious hypersensitivity reactions have been reported with intravenous tocilizumab and may be more severe and potentially fatal in patients with hypersensitivity during previous infusions, even after premedication with steroids and antihistamines.
Sources for this answer
- RoActemra 20mg/ml Concentrate for Solution for InfusionRoche Products Limited · emc · SmPC §4.4 Special warnings and precautions for use · Version 37Document updated
Sources checked