Answer
Macitentan (Opsumit) is contraindicated in patients with severe hepatic impairment, with or without cirrhosis, or baseline hepatic aminotransferases (AST and/or ALT) greater than 3 times the upper limit of normal.
Sources for this answer
- Opsumit 10mg film coated tablets (Great Britain)Janssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §4.3 Contraindications · Version 29Document updated
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