Answer
Rifampicin 600 mg daily reduced steady-state macitentan exposure by 79% without affecting active metabolite exposure, potentially reducing macitentan efficacy, so the combination should be avoided.
Sources for this answer
- Opsumit 10mg film coated tablets (Great Britain)Janssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §4.5 Interaction with other medicinal products · Version 28Document updated
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