Answer
Macitentan given as repeated doses of 10 mg once daily did not affect S-warfarin or R-warfarin exposure after a single 25 mg warfarin dose, nor did it affect warfarin’s effect on International Normalised Ratio (INR).
Sources for this answer
- Opsumit 10mg film coated tablets (Great Britain)Janssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §4.5 Interaction with other medicinal products · Version 28Document updated
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