Answer
In sofosbuvir + velpatasvir, sofosbuvir inhibits the hepatitis C virus NS5B RNA-dependent RNA polymerase, essential for viral replication, while velpatasvir targets NS5A, essential for RNA replication and assembly of viral particles.
Sources for this answer
- Sofosbuvir/Velpatasvir Gilead 400 mg/100 mg film coated tablets.Gilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 22Document updated
Sources checked