Answer
Elexacaftor, ivacaftor and tezacaftor in Kaftrio are primarily metabolised by CYP3A4 and CYP3A5.
Sources for this answer
- Kaftrio 75 mg/50 mg/100 mg film-coated tabletsVertex Pharmaceuticals (Europe) Limited · emc · SmPC §5.2 Pharmacokinetic properties · Version 16Document updated
Sources checked