Answer
In Kaftrio, elexacaftor and tezacaftor bind different CFTR sites and additively improve F508del-CFTR processing and trafficking to the cell surface, while ivacaftor increases channel-opening probability, together increasing surface CFTR quantity, function and chloride transport.
Sources for this answer
- Kaftrio 75 mg/50 mg/100 mg film-coated tabletsVertex Pharmaceuticals (Europe) Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 16Document updated
Sources checked