Answer
Combining posaconazole and vincristine has been associated with neurotoxicity, seizures, peripheral neuropathy, syndrome of inappropriate antidiuretic hormone secretion and paralytic ileus; posaconazole should be reserved for patients receiving vincristine who have no alternative antifungal treatment options.
Sources for this answer
- Noxafil 40mg/ml oral suspensionMerck Sharp & Dohme (UK) Limited · emc · SmPC §4.4 Special warnings and precautions for use · Version 29Document updated
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