Answer
Pitolisant hydrochloride has a plasma half-life of 10–12 hours, which doubles in moderate hepatic impairment (Child-Pugh B) and is longer in CYP2D6 poor metabolisers than in extensive metabolisers.
Sources for this answer
- Wakix 4.5 mg film-coated tabletsBioprojet UK Limited · emc · SmPC §5.2 Pharmacokinetic properties · Version 6Document updated
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