Answer
Mirtazapine may impair pitolisant hydrochloride efficacy through histamine H1-receptor antagonism, possibly cancelling the effects of endogenous histamine released in the brain by treatment, so an alternative should be used.
Sources for this answer
- Wakix 4.5 mg film-coated tabletsBioprojet UK Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 6Document updated
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