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Medicines methotrexateQuestion & answer

methotrexate · Medicine question

What is the main route of methotrexate elimination from the body?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Methotrexate is eliminated primarily by renal excretion into urine, with elimination dependent on dosage and route of administration.

Sources for this answer

Methotrexate 25 mg/ml InjectionHospira UK Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 28Document updated 7 September 2026

Sources checked 8 November 2026

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methotrexate

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