What is ponatinib’s mechanism of action?

Ponatinib is a potent pan-BCR-ABL tyrosine kinase inhibitor whose carbon–carbon triple bond enables high-affinity binding to native and mutant ABL, including T315I; it also inhibits other kinases, with cellular activity against RET, FLT3, KIT, and FGFR, PDGFR and VEGFR families.