What is known about the passage of Skudexa’s active ingredients into human breast milk?

Skudexa has no controlled human-milk excretion studies; dexketoprofen excretion is unknown, while tramadol and metabolites occur in small amounts (approximately 0.1% of the maternal tramadol dose; infant intake averages 3% of the maternal weight-adjusted dose immediately postpartum with oral doses ≤400 mg/day), and Skudexa is contraindicated during breastfeeding.