Answer
In Skudexa, dexketoprofen inhibits COX-1 and COX-2 to reduce prostaglandin synthesis, while tramadol and its active metabolite act at opioid receptors; tramadol also inhibits norepinephrine and serotonin reuptake in vitro, which may contribute to pain relief.
Sources for this answer
- Skudexa 75 mg/25 mg film-coated tabletsA. Menarini Farmaceutica Internazionale SRL · emc · SmPC §5.1 Pharmacodynamic properties · Version 12Document updated
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