Answer
Subcutaneous methylnaltrexone bromide (Relistor) decreased fertility in rats at 150 mg/kg/day, while doses up to 25 mg/kg/day (18 times human AUC exposure at a subcutaneous dose of 0.3 mg/kg) did not affect fertility or general reproductive performance.
Sources for this answer
- Relistor 12mg/0.6ml solution for injection vialsBausch Health Ireland Limited · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 1Document updated
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