Answer
In vitro, methylnaltrexone bromide has eightfold lower antagonist potency at kappa-opioid receptors (Ki = 230 nM) than at mu-opioid receptors (Ki = 28 nM).
Sources for this answer
- Relistor 12mg/0.6ml solution for injection vialsBausch Health Ireland Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated
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