sacubitril + valsartan · Medicine question

What effect on blood pressure was observed when sildenafil was added to sacubitril + valsartan in patients with hypertension?

iatroX medicinesPublished 8 November 2026

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Adding a single dose of sildenafil to sacubitril + valsartan at steady state in patients with hypertension produced a significantly greater blood pressure reduction than sacubitril + valsartan alone.

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Entresto film-coated tabletsNovartis Pharmaceuticals UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 14Document updated 30 September 2025

Sources checked 8 November 2026

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