sacubitril + valsartan · Medicine question

Can sacubitril + valsartan cause angioedema?

iatroX medicinesPublished 8 November 2026

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Yes, angioedema has been reported with sacubitril + valsartan; if it occurs, treatment must be stopped immediately, appropriate therapy and monitoring provided until complete and sustained resolution, and the medicine must not be restarted.

Sources for this answer

Entresto film-coated tabletsNovartis Pharmaceuticals UK Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 14Document updated 30 September 2025

Sources checked 8 November 2026

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