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Please give the approach to depression in elderly

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MSt MRCGP.

Posted: 29 September 2026Updated: 29 September 2026 Guideline-Aligned (High Confidence) Clinically Reviewed

Assess: Ask about low mood or loss of interest, symptom duration and impact on daily functioning; review physical illness, medicines, alcohol use, bereavement, isolation, support and previous depression or self-harm . Ask directly about suicidal thoughts, plans and intent, assess protective factors, and arrange help according to risk . Use a validated depression questionnaire alongside clinical assessment, assess mental state and cognition, and consider examination or investigations where indicated . If dementia is present, identify and monitor behavioural changes alongside depressive symptoms .

Manage: Agree a plan through shared decision-making, offering information and support and choosing active monitoring, guided self-help, psychological therapy or an antidepressant according to severity, needs and preferences . For mild-to-moderate depression in dementia, consider psychological treatment and do not routinely offer antidepressants unless indicated for a pre-existing mental health problem . Behavioural approaches can also help address behavioural changes in Alzheimer disease . If prescribing, discuss adverse effects, withdrawal and treatment duration; review comorbidities and medicines, as trazodone may cause orthostatic hypotension and somnolence more often in older people ,. Arrange regular follow-up to review symptoms, functioning, adherence, adverse effects and suicide risk; if improvement is inadequate, reconsider the diagnosis and treatment plan .

Educational content only. Always verify information and use clinical judgement.

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