Depression

Assessment and treatment of depressive disorders.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MSt MRCGP (General Practitioner)

Last reviewed: 21 October 2025

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regional clinical guidance

Depression: guidance by region

Recommendations, thresholds and pathways can differ. Open the page written for the jurisdiction you need.

United StatesMajor depressive disorder assessment and treatmentMental health · reviewed 2026-08-20 CanadaDepressionMental health · reviewed 2026-08-20 AustraliaDepressionMental health · reviewed 2026-08-20

Clinical Guidelines

CKS: Depression

ESMO: Clinical Practice Guideline: Anxiety and Depression

NICE guideline [NG222]: Depression in adults: treatment and management

NICE: Depression in adults: treatment and management

SIGN 114: Non-pharmaceutical management of depression

ACOG Clinical Practice Guideline No. 4: Treatment and Management of Mental Health Conditions During Pregnancy and Postpartum

ACP Clinical Guideline: Nonpharmacologic and Pharmacologic Treatments of Adults in the Acute Phase of Major Depressive Disorder

American Psychiatric Association Practice Guideline for the Treatment of Patients with Major Depressive Disorder

Clinical Practice Guideline for the Treatment of Depression Across Three Age Cohorts

ESMO Clinical Practice Guideline: Anxiety and Depression in Adult Cancer Patients

US Preventive Services Task Force Recommendation: Screening for Depression and Suicide Risk in Adults

VA/DoD Clinical Practice Guideline for the Management of Major Depressive Disorder (MDD) (2022)