What are the first-line pharmacological treatments for adults diagnosed with temporal lobe epilepsy?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed

Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

For adults with focal seizures, which include temporal lobe epilepsy, the first-line monotherapy options are lamotrigine or levetiracetam. If the first choice is unsuccessful, consider the other of these options .

Key References

NG217 - Epilepsies in children, young people and adults

What are the first-line pharmacological treatments for adults diagnosed with temporal lobe epilepsy?

Key References

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