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Pre-treatment physiological assessment — SCE Respiratory MCQ

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HardLung CancerPre-treatment physiological assessmentSCE Respiratory

A patient being considered for lung resection has impaired spirometry and a suboptimal shuttle-walk test. CPET shows peak oxygen uptake 11 mL/kg/min and a VE/VCO2 slope of 42. How should this be interpreted?

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Correct answer: AHigh surgical risk requiring reconsideration of radical-treatment modality

Explanation lettering: D = shown as A · A = shown as C · C = shown as D

D is correct. The 2025 ERS/ESTS guideline identifies peak VO2 below 12 mL/kg/min or VE/VCO2 slope above 40 as signals of high surgical risk. Both are adverse here, so the MDT should integrate tumour benefit, resection extent, comorbidity and non-surgical radical options. A value just above the historical 10 threshold is not low risk, resting saturation does not override CPET, and VE/VCO2 is a valid prognostic measure.

Reference: https://publications.ersnet.org/content/erj/66/5/2500156