Pre-treatment physiological assessment — SCE Respiratory MCQ
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Correct answer: A — High surgical risk requiring reconsideration of radical-treatment modality
Explanation lettering: D = shown as A · A = shown as C · C = shown as D
D is correct. The 2025 ERS/ESTS guideline identifies peak VO2 below 12 mL/kg/min or VE/VCO2 slope above 40 as signals of high surgical risk. Both are adverse here, so the MDT should integrate tumour benefit, resection extent, comorbidity and non-surgical radical options. A value just above the historical 10 threshold is not low risk, resting saturation does not override CPET, and VE/VCO2 is a valid prognostic measure.
Reference: https://publications.ersnet.org/content/erj/66/5/2500156